草莓和石榴中的特殊代谢产物或能有效抑制炎性肠病的进展
西方诗歌
来源:本站
2019-06-10

草莓和石榴中的特殊代谢产物或能有效抑制炎性肠病的进展

Theimporta,thefuncti(UroA),amajormicrobialmetabolitederivedfrompolyphenolicsofberriesandpomegranatefruitsdisplaysanti-inflammatory,anti-oxidative,,weshowthatUroAanditspotentsyntheticanalogue(UAS03)significctivationofarylhydrocarbonreceptor(AhR)-nuclearfactorerythroid2–relatedfactor2(Nrf2)-,treatmentwiththesecompoundsattenuatedcolitisinpre-clinicalmodelsbyrem,theresultshighlighthowmicrobialmetabolitesprovidetwo-prongedbeneficialactivitiesatgutepitheliumbyenhancingbarrierfunctionsandreducinginflammationtoprotectfromcolonicdiseases.。